In 1957, a virologist who had studied several infectious diseases among remote peoples, came to New Guinea to study kuru. Carleton Gajdusek wanted to uncover the cause of this unique and always fatal disease. He searched for sources of toxins in the Fore's diet and environment.

He conducted epidemiological studies and sent samples of brain tissue to the United States to be studied by a neuropathologist. Because there was no sign of inflammation in the bodies or brains of the kuru victims, and because kuru tended to appear within certain families, Gajdusek at first believed kuru was an inherited genetic disorder.

 

 

 

In 1959 Gajdusek's work came to the attention of William Hadlow, a research veterinarian who was studying a remarkably similar disease, called scrapie, in sheep. Like kuru, scrapie was a fatal disease that gradually destroyed the brains of sheep, leaving the brain full of holes and producing no immune response. And very importantly, scientists knew that scrapie was infectious.



The similarities between kuru and scrapie led Gajdusek to begin experiments to show that kuru could be transmitted to chimpanzees. He then went on to show that classic Creutzfeldt-Jakob disease (CJD), another spongiform disease in people, was also transmissible.

Ultimately, the rapid spread of kuru was linked to the Fore's funeral rituals: the Fore cooked and ate their dead relatives. This practice was only carried out by the Fore women and children, who lived apart from the men. This explains why men were rarely infected, and why cases appeared within families. The Fore quickly stopped eating their dead, and the spread of the disease stopped. Unfortunately, because of kuru's long incubation time, there are still a few kuru cases among the Fore each year. The people who come down with kuru today are in their 50s and 60s, which means that they have been harboring the disease ever since they ate infected tissue as young children.